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Cake day: July 1st, 2023

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  • protist@mander.xyztoAsklemmy@lemmy.mlHave you ever smoked crack? What was it like?
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    22 days ago

    This is pretty easy to search, but also intuitive when you consider crack is most often smoked vs cocaine being absorbed through your nasal mucosa. Here are a few highlights from this comprehensive review, which also covers the very real socioeconomic differences in use patterns:

    By virtue of its hydrophilicity, cocaine hydrochloride is generally consumed by ‘snorting.’ ‘Crack’ cocaine is generally the only form of cocaine that is smoked—this is due to the fact that cocaine hydrochloride has an elevated boiling point and does not vaporise at the temperatures of combustion.

    ®outes that involve the respiratory system…allow for the stimulant to reach the brain circulation in around 6 to 8 s; the inhalation route presents higher peak plasma concentrations that are reached faster when compared to intranasal administration. It should be noted that, for the intranasal route, the vasoconstrictive properties of cocaine slow down the drug’s own absorption, causing a 60-min delay of peak plasmatic concentrations. In terms of bioavailability, the inhalation route has the greatest bioavailability, which surpasses 90%, while the intranasal route has roughly 80%.

    The abuse and dependence of cocaine is strongly related to the drug’s capacity to induce the release of dopamine within the mesocorticolimbic circuit (also known as the reward system). As the user continues to consume cocaine, desensitization occurs and so larger doses are necessary to induce stimuli of the same magnitude as before, as well as to minimize withdrawal symptoms.

    Another difference of inhalation vs intranasal:

    Smoking ‘crack’ leads to the formation of another biomarker of exposure, AEME, which is the main product of cocaine’s thermal degradation. In vitro and in vivo studies show that AEME appears to have effects on the cardiovascular system, by acting as a muscarinic agonist. Furthermore, neurotoxic effects were also reported for this metabolite.


  • protist@mander.xyztoAsklemmy@lemmy.mlHave you ever smoked crack? What was it like?
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    22 days ago

    Let’s be real though, crack is significantly more addictive than regular cocaine. The high is higher, it lights up all the dopamine receptors in your brain. The high is much shorter, and the crash is much harder, which pushes users to use more to avoid intolerable withdrawal symptoms. Cocaine is “mellower” in pretty much every way. All the bad parts of cocaine use are only magnified in crack use. All this is completely independent of fucked up drug policy







  • That’s quite a fantasy you’re telling yourself. A huge portion of China’s people’s wealth is wrapped up in real estate, and tens of millions of stalled residential units have already been purchased by the Chinese people, and that money is now gone, taken by the developers.

    The IMF recommendation here was “to deploy ‘one-off’ fiscal resources to complete and deliver pre-sold properties or compensate homebuyers.” That would literally be rescuing the Chinese people who were burned by developers. Instead, the Chinese government is supporting the tech and manufacturing industries. Don’t pretend like China is some paradise where the common people aren’t getting fucked




  • I’ve been paying $70/mo for gigabit fiber for like 6 years now. It’s been the exact same price every month that entire time. I had to reach out to the Google Fiber people maybe once for a technical issue, and it was resolved quickly with a prorated discount for my downtime.

    I just can’t stress enough what a breath of fresh air this has been vs Time Warner/Spectrum and then later AT&T I’ve had at this same address. How many times did I have to call to wait on hold to tell them my service was broken, or threaten to cancel my service so they would lower my rate back down to what it was before they tried to jack it up again? How many technicians did I have to have come to my house for stupid bullshit? Also, the other two ran bare cable barely buried from the junction box to my house, where Google installed a fucking conduit in the ground that can easily be reused.

    Google is the best ISP by a hundred miles, imo. Just use a VPN.