I’m typing this from a Nothing 2 that I’ve had for almost a year. Don’t think there’s anything large I’m missing, almost a direct replacement from my Samsung S20 I had before meaning no SD card, no IR, etc on either. Maybe the main thing missing which I probably could recreate with other apps is Goodlock and it’s configurable gestures for edge of the screen but I’ve unlearned those macros and am fine.
Probably the benefits of reading on eink which is less straining on the eyes but in a smaller form factor