A lot of great options named in the thread but I’ll also add Slice and Dice and Crypt of the NecroDancer. Seconding FTL too, that was one of my top games of the 2010’s.
I also recommend Cobalt Core, which is not quite patient as a past November release. Great for FTL fans or anyone that likes tactical card battlers.
Civ5 has been my favorite in the series. They did a great job with the AI on that one, and it gave the game so much replay value for me.